Medical marijuana can help manage the symptoms of Ulcerative Colitis (UC). Ulcerative colitis is a chronic inflammatory disease that causes ulcers and inflammation in the colon and rectum. It's a type of inflammatory bowel disease (IBD).
Abdominal pain and cramping
Bloody diarrhea
Weight loss
Fever
Feeling the need to have a bowel movement even after emptying your bowels
Loss of appetite
Rectal bleeding
Anemia
Skin sores
Joint pain
Ulcerative proctitis: Inflammation is limited to the rectum
Pancolitis: Inflammation affects the entire colon
Distalcolitis: Inflammation affects the left side of the colon
Abnormal immune response
Genetics
Microbiome
Environmental factors
Interactions between a virus or bacterial infection in the colon and the body's immune response.
Most people with UC experience periods of remission when they don't have symptoms, followed by flare-ups when they do. With treatment, most people with UC can live active lives.
According to a study published by the National Institute of Health, medical cannabis can relieve symptoms of ulcerative colitis such as reduced appetite, diarrhea, and abdominal pain. Cannabis is known to affect pain and discomfort via psychotropic effects.
Cannabis can also modulates the endocannabinoid system which acts on the nervous system, peripheral tissues, and the immune system. This system is composed of cannabinoid (CB) receptors 1 and 2, endogenous endocannabinoids, and associated enzymes.
It is hypothesized that cannabis and its derivatives may work through this pathway to decrease inflammation on the gut and provide positive therapeutic effects on ulcerative colitis.